Vitamin D Associated Peculiarities in Women with Mild Covid-19 and Effect of Calcifediol on the Level of Vitamin D and Possibly, on Disease Outcome - Prospective Pilot Study

Grigoryan Karen, Mikaberidze Khatia, Ratiani Levan, Goginashvili Nino, Pachkoria Elene, Gabunia Luiza, Sanikidze Tamar, Pkhaladze Maia, Metreveli Levan, Ghambashidze Ketevan


Presented study provides information about prospective pilot study concerning the vitamin D  in women with mild COVID-19 (SARSCoV2) and effect of Calcifediol on the vitamin D level and possibly, on disease outcome.

The study involved 30 women aged 48 to 72 years who were treated for a mild form of new coronavirus infection between 1.09.2020 - 1.12.2020 at the First University Clinic of TSMU.

In all patients, the new type SARSCoV2 was confirmed by polymerase chain reaction performed with reagents-Xpert Xpress SARS-CoV-2 (Cepheid, USA) on GeneXpert (USA) analyzer (closed system). D-dimer, ferritin, C-reactive protein and lactate dehydrogenase were detected upon the hospital admission. Vitamin D was defined using Roche reagents (electrochemiluminescence method; Roche HITACHICobase-411 device- Switzerland).

On the 1st day of hospital admission, all patients received 0.266 mg (1 capsule) of calcifediol (16000 UI) in the form of the drug Hydroferol (FAES FARMA, S.A., Spain). Vitamin D and -reactive protein was defined repeatedly on the 5th day of treatment.

Results: Studies have shown that on the 5th day after hydroferol administration the vitamin D level in patients with COVID-19 was significantly increased [16.8 (12.2–24.2) vs. 56.4 (52.3–62.2), p<0.0001]. Negative relationship was found between the onset of symptoms and baseline vitamin D levels (F = 5.9223, p <0.026). The negative relationship was found between the repeatedly defined levels of vitamin D and C-reactive protein (F=12.82, p<0.009) also, pointing on the positive treatment effect of vitamin D on the course of mild form of Covid-19. None of the patients required continued treatment in the intensive care unit and were discharged home with satisfactory state.

Conclusion: Vitamin D supposedly plays the important role in pathogenesis and outcome of SARSCoV2 virus infected patients. Additional large-scale randomized placebo-controlled studies on the role of vitamin D in COVID-19 pathogenesis are needed.


Vitamin D, Covid-19, Calcifediol, women.

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